Abstract:
Significance of leptin and cholesterol profile in health and disease especially related to hypertension and other related medical disorders has extensively been reviewed. Positive relationship of low-density lipoprotein cholesterol (LDL-C) and serum leptin was revealed in several studies. However, there are still controversies about the gender and age-based serum leptin and cholesterol profile in non-obese normal control male (NCm) and female (NCf) subjects, and nonobese hypertensive male (HPTm) and female (HPTf) subjects, as it was suggested that the change in leptin and cholesterol profile related to body mass index (BMI) might also be due to age, race, type of obesity and other factors. Hence, it was proposed in the present study to investigate the association of age with corresponding serum leptin and cholesterol profile levels. The ELISA-kit methods were employed, and standard statistical analysis were carried out. Significant increased serum leptin, LDL-C and high-density lipoprotein cholesterol (HDL-C) for HPTm and HPTf; significant association of age with serum leptin, total cholesterol (TC), LDL-C in all groups, and with HDL-C only for HPTm; and significant association of serum leptin with TC, LDL-C and HDL-C (in all groups except for HDL-C in HPTf) were obtained. The current study reveals quite interesting and new information for the association existing between age of subjects and their serum leptin and cholesterol profile levels in non-obese healthy and hypertensive subjects. This report, hence, seems promising for future studies.
Page(s):
323-328
DOI:
DOI not available
Published:
Journal: International Journal of Biology and Biotechnology, Volume: 19, Issue: 3, Year: 2022
Keywords:
age and gender
,
Hypertension
,
Serum leptin
,
normotension
,
serum cholesterol profile
,
nonobese hypertensive subjects