A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory | [Pakistan Armed Forces Medical Journal • 2023]

Author(s):

1. Muhammad Usman Munir: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

2. Muhammad Aamir: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

3. Zujaja Hina Haroon: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

4. Sobia Irum Kirmani: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

5. Afshan Yasir: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

6. Hunain Habib: Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi,,Pakistan

Abstract:

Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency Study Design: Cross-sectional survey.Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Aug 2020 to Jan 2021.Methodology: The study was conducted on 129 individuals aged 2-16 years. History, axiological data and biochemical parameters were assessed to establish GH deficiency for short stature workup.Results: Out of 129 individuals, 76(59%) boys and 53(41%) girls reported GH stimulation tests. 81(62.3%) children were in 2 years, 34(82.9%) fell in <3rd percentile. GH Stimulation test post-Levo Dopa was performed in 102(78.46%) patients. 49(37.4%) patients responded inadequately to the GH stimulation test. The adequate response to the GH Stimulation test improved as the percentile declined from the 50th to the 3rd percentile.Conclusion: GH stimulation test results can only partially rely upon though their importance remains in combination with other short-stature workup parameters for ruling out growth hormone deficiency.

Page(s): 477-480

DOI: 10.51253/pafmj.v73i2.7906

Published: Journal: Pakistan Armed Forces Medical Journal, Volume: 73, Issue: 2, Year: 2023

Keywords:

Short stature , words Growth hormone stimulation tests , Height percentile

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