Abstract:
The virus replicates by infecting cells of the host and making copies by using components of the host cell. Circovirus is one of the most common viruses present in various animals including pigs, pigeons, parrots, etc. It belongs to the Circoviridae family and is a single-stranded DNA virus (ssDNA). It is characterized by various symptoms like diarrhea, weight loss, anemia, allergy, etc. To date, there is no direct treatment available for this virus. BFDV is a type of circo virus and affects pigeons and parrots. Getting active compounds or phytochemicals from plants to use for various diseases is a very common process. Various phytochemicals obtained from plant fruits, grains, etc. can be used as a cure for various diseases without causing any damage to the hosts. In the study, the families of plant Meliaceae, Moraceae, Moringaceae, Ranunculaceae, Zingiberaceae, Fabaceae, Aceraceae, Apocynaceae, Asteraceae, Polygonaceae, and Poaceae or Graminae are being targeted as they proved to have highest medicinal properties among all plant families. The basic target is to activate the immune system for the invasion of the virus by not harming the host. Various bioinformatics tools including PDB, Dr. Duke, modeler 10.1, chimera 1.15, PubChem, server, FTsite server NCBI, BLAST, swiss model, clustal W, and protein molecular weight are used in the research too. Further, the ability of the phytochemicals to be used as drugs is confirmed by verifying their various characteristics like Blood Brain Barrier (BBB), Gastrointestinal absorption (GI Absorption), solubility, Lipinski’s rule of 5, toxicity, carcinogenicity, and mutagenicity. The docking process showed the interactions between proteins of causing agent and the phytochemicals. DFT confirmed the energy gaps and verified the results. After screening more than 3000 phytochemicals and selecting 224, LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDE proved to be the best phytochemical to inhibit BFDV isolates.
Page(s):
38-38
DOI:
DOI not available
Published:
Journal: Abstract Book on Second International Conference on Recent Approaches in Plant Sciences (RAPS-23) 4-5 May 2023 , Volume: 0, Issue: 0, Year: 2023