Terminal galactose as cancer recognition marker: Computing analysis with implications of vicinal sugars, linkage and anomery. | [Pakistan Journal of Zoology • 2008]

Author(s):

1. Afshan Kaleem: Institute of Molceular Sciences and Bioinformatics, Lahore, Pakistan

2. Ahmed Khurshid: Institute of Molceular Sciences and Bioinformatics, Lahore, Pakistan

3. Ishtiaq Ahmad: Institute of Molceular Sciences and Bioinformatics, Lahore, Pakistan

4. Evelyne Walker-Nasir: Institute of Molceular Sciences and Bioinformatics, Lahore, Pakistan

5. Nasir-Ud-Din: Institute of Molceular Sciences and Bioinformatics, Lahore, Pakistan

6. Sadia Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

7. M. Iqbal Choudhary: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

8. Nasir-Ud-Din: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

9. A. R. Shakoori: School of Biological Sciences, University of the Pun jab, Lahore, Pakistan

Abstract:

Carbohydrate structures on proteins play vital role as recognition markers in several diseases including g cancer. The carbohydrate chains are dramatically - altered in cancer cells compared to normal cells, both in structure and quantity. The mucin O-glycans show several cancer associated structures like T- (Gal-GalNAc-Ser/Thr) and Tn-antigen (GaINAc-Ser/Thr). Terminal galactose (Gal) in macro type O-glycan oligosaccharide structures is known to act as t recognition marker for several cancer-associated lectins like galectin and mistletoe lectins. This study describes the role of terminal Gal, inclusive of its anomery, linkage and that of sugar residues vicinal to terminal Gal in oligosaccharide structures of glycoproteins as an epitope or as a recognition marker in cancer.

Page(s): 135-143

DOI: DOI not available

Published: Journal: Pakistan Journal of Zoology, Volume: 40, Issue: 2, Year: 2008

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