To Evaluate the Toxic Effects of Lithium Carbonate on Granule Cells Count of Rat Cerebellum | [Pakistan Journal of Medical and Health Sciences • 2021]

Author(s):

1. TAZEEN KOHARI: Islam Medical and Dental College,Pasrur, Sialkot, Pakistan

2. ZAFAR MALIK: Sahara Medical College Narowal, Pakistan

3. AFTAB AHMED: M. Islam Medical College,Gujranwala, Pakistan

4. FAIZA IRSHAD: M. Islam Medical College,Gujranwala, Pakistan

5. AAQIBA RASHEED: Islam Medical and Dental College,Sialkot, Pakistan

6. RANA M ZESHAAN: University of health sciences, Sialkot, Pakistan

Abstract:

Aim: To study the damaging effect of chronic ingestion of 20 mg/kg body weight/OD of lithium carbonate on cerebellargranule cells. Methods: However, there is scanty documented information about the cerebellar toxicities of lithium carbonate on granule neurons. Therefore the present study is designed to observe the microscopic changes of granule neurons in rat cerebellum. For this experimental study 20 animals were used, they were divided into two groups, each comprising of 10 animals. Results: Group-A received normal lab diet and water ad libitum while group B received lithium carbonate 20 mg/kg/OD for 2 weeks and 6 weeks respectively. Micrometry was done on granule cells count. Conclusion: Highly significant changes of granule cells count were observed even at therapeutic doses. Lithium carbonate causes oxidant injury to granule neuronal cells in rat cerebellum.

Page(s): 1149-1151

DOI: 10.53350/pjmhs211561149

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 15, Issue: 6, Year: 2021

Keywords:

Oxidant injury , Incoordination , Cerebellar degeneration

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