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A lignan with glucose uptake activity in 3T3-L1 adipocytes from the stem bark of Knema patentinervia
Author(s):
1. Muhammad Taher: Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
2. Mohamed Zaffar Ali Mohamed Amiroudine: Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
3. Juliana Md Jaffri: Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
4. Mohamad Shahreen Amri: Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
5. Deny Susanti: Department of Chemistry, Faculty of Science, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
6. Shafida Abd Hamid: Department of Chemistry, Faculty of Science, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
7. Mohamad Fazlin Rezali: SIRIM Berhad (National Metrology Laboratory),Lot PT, Bandar Baru Salak Tinggi, Sepang, Selangor,Malaysia
8. Choudhury Mahmood Hassan: Manarat International University,Road No 106, Gulshan-2, Dhaka,Bangladesh
9. Roger W Read: The School of Chemistry, The University of New South Wales,UNSW Sydney NSW,Australia
10. Qamar Uddin Ahmed: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia
11. Farediah Ahmad: Department of Chemistry, Faculty of Science,Universiti Teknologi Malaysia, Skudai, Johor,Malaysia
Abstract:
A new naturally occurring dibenzylbutyrolactone lignan named isocubebinic ether has been isolated from Knema patentinervia. The structure was established by spectroscopic methods, which include Ultraviolet, Infrared, Nuclear Magnetic Resonance and Mass Spectrometry. The compound showed activity in the stimulation of glucose uptake by 3T3-L1 adipocytes.
Page(s): 1335-1339
DOI: DOI not available
Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 30, Issue: 4, Year: 2017
Keywords:
Knema patentinervia , lignan , glucose uptake , 3T3L1 adipocytes
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