Salivary and imaging-based biomarkers of radiation therapy-induced xerostomia | [Journal of Pakistan Medical Association • 2021]

Author(s):

1. Azlina Ahmad: School of Dental Sciences, Universiti Sains Malaysia Health Campus,Kubang Kerian, Kelantan, Malaysia

2. Muhammad Qasim Saeed: Institute of Dentistry, CMH Lahore Medical College,Lahore,Pakistan

3. Sarah Ghafoor: Department of Oral Biology, University of Health Sciences, Lahore, Pakistan

4. Norsila Abdul Wahab: School of Dental Sciences, Universiti Sains Malaysia Health Campus,Kubang Kerian, Kelantan, Malaysia

5. Saira Atif: School of Dental Sciences, Universiti Sains Malaysia Health Campus,Kubang Kerian, Kelantan, Malaysia

Abstract:

Biomarkers are anatomical characteristics or naturally occurring measurable molecules indicating physiological or pathological state of an individual. These biomarkers have the potential to detect or predict diseases at an early stage, which is particularly beneficial in timely management of common complications of radiation therapy done in head and neck cancer treatment regime. Xerostomia is one of the most common oral complaints of radiation therapy. Saliva has an abundance of protein biomarkers; however, those related to post-radiation therapy xerostomia need to be explored further. Textural and imaging-based biomarkers are helpful in predicting xerostomia in such patients. This narrative review provides an account of salivary protein and imaging-based biomarkers of radiation therapy-induced xerostomia in head and neck cancer patients.

Page(s): 938-942

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 71, Issue: 3, Year: 2021

Keywords:

Radiotherapy , chemotherapy , Salivary glands , head and neck cancer , mouth dryness

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