Amenorrhea after chemotherapy in breast cancer patient | [Journal of Ayub Medical College • 2020]

Author(s):

1. Ramchandani Ravi: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

2. Ghulam Haider: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

3. Khalil Ahmed: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

4. Abdus Sami: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

5. Saima Zahoor: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

6. Ramchandani Lata: Department of Medical Oncology, Jinnah Postgraduate Medical Centre,Karachi-,Pakistan

Abstract:

Background: This study was conducted to determine the frequency of amenorrhea after chemotherapy among breast cancer patients”. Methods: Total 201 premenopausal females (having menstruation during the past 6 months at the time of diagnosis) of age 15-45 years and had confirmed diagnosis of breast cancer requiring chemotherapy were included in the study using non-probability consecutive sampling technique. Amenorrhea within 6 months after the completion of chemotherapy was labelled as chemotherapy induced amenorrhea. Data was entered and analysed using SPSS-23. Results: The mean age of the patients was reported as 37.06±5.68 years. Majority of the females were married (86.6%) & multigravida (81.1%). Most of the patients (23.9%) received neoadjuvant chemotherapy followed by surgery and radiotherapy. A total of 129 patients received Adriamycin plus cyclophosphamide followed by paclitaxel as chemotherapy regimen. Out of 201 females, 184 (91.5%) experienced amenorrhea after start or completion of chemotherapy. Conclusion: The frequency of CIA was very high among breast cancer patients in our study, long term follow-up is needed to see input of CIA on future fertility.

Page(s): 73-77

DOI: DOI not available

Published: Journal: Journal of Ayub Medical College, Volume: 32, Issue: 1, Year: 2020

Keywords:

Breast cancer , chemotherapy , Chemotherapy induced amenorrhea , Amenorrhea

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