An Evaluation of Thiol/Disulphide Homeostasis and HDL Values in Patients with Cholelithiasis: A Prospective Case-control Study | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2022]

Author(s):

1. Guniz Yanik Ustuner: Department of Internal Medicine, Bursa Cuneyt Yildiz State Hospital,Bursa,Turkey

2. Fatma Ebru Akin: Department of Gastroenterology, Ankara Yildirm Beyazit University, Ankara City Hospital,Ankara,Turkey

3. Suadiye Saglam: Department of Biochemistry, Ankara Yildirm Beyazit University, Ankara City Hospital,Ankara,Turkey

4. Gamze Gok: Department of Biochemistry, Ankara Yildirm Beyazit University, Ankara City Hospital,Ankara,Turkey

5. Ozcan Erel: Department of Biochemistry, Ankara Yildirm Beyazit University, Ankara City Hospital,Ankara,Turkey

6. Osman Ersoy: Department of Gastroenterology, Ankara Yildirm Beyazit University, Ankara City Hospital,Ankara,Turkey

Abstract:

Objective: To determine the changes in thiol/disulphide homeostasis in patients determined with asymptomatic cholelithiasis and to investigate any potential correlation between these thiol-disulphide parameters and HDL cholesterol. Study Design: A descriptive, comparative study. Place and Duration of Study: Ankara City Hospital between 15 September and 31 December 2019. Methodology: This study included 42 patients aged 18-70 years, who presented at the Gastroenterology Clinic and were diagnosed with cholelithiasis on ultrasound examination. A control group was formed of 51 healthy volunteers aged 18-70 years. Thiol/disulphide homeostasis and HDL cholesterol was noted and compared between the groups. Results: The mean age was 44.16 ± 13.35 years in cholelithiasis patient group and 31.88±13.27 years in the control group. The triglyceride, VLDL, total cholesterol/HDL, and non-HDL levels were signi cantly higher and HDL level was signi cantly low in the patient group (both p <0.05). Regarding thiol-disulphide balance, native thiol, total thiol, and albumin values were found to be statistically signi cantly low in the patient group (p <0.05), and the IMA, index-1, index-2, and index-3 values were signi cantly high (p <0.05). Conclusion: The oxidant/antioxidant balance shifted towards oxidation in patients with asymptomatic gallstones. The non-HDL value was increased. There was a positive correlation between the thiol-disulphide parameters and the non-HDL value. The increasing non-HDL amount could be e ective in the pathogenesis of gallstone disease by disrupting the oxidative balance.

Page(s): 424-429

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 4, Year: 2022

Keywords:

Oxidative stress , Cholelithiasis , Lipid pro le , NonHDL , Thioldisulphide homeostasis

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