A review on aspects of current pharmacotherapies for covid-19 | [Pakistan Journal of Science • 2022]

Author(s):

1. S. Areej: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences,Lahore,Pakistan

2. M. Ahmad: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan; Department of Pharmacology, Riphah International University, Lahore, Pakistan.

3. G. Abbas: Department of Animal Production, Riphah College of Veterinary Sciences, Riphah International University,Lahore,Pakistan

4. A. Majeed: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences,Lahore,Pakistan

5. B. M. Beg: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences,Lahore,Pakistan

6. A. Iqbal: Department of Pathobiology, Riphah College of Veterinary Sciences, Riphah International University,Lahore,Pakistan

7. A. Basharat: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan; Department of Pharmacology, Riphah International University, Lahore, Pakistan.

8. R. M. Z. Mushtaq: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan; Lords College of Pharmacy Lahore, Pakistan

9. W. Ahmad: Institute of Microbiology, University of Veterinary and Animal Sciences Lahore,Pakistan

10. S. Aroosa: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences,Lahore,Pakistan

11. S. Jaffery: Faculty of Agriculture, University of Agriculture Faisalabad,,Pakistan

12. S. B. Shabbir: Institute of Microbiology, University of Veterinary and Animal Sciences Lahore,Pakistan

Abstract:

The novel coronavirus has infected over 609,848,852 individuals throughout the world with a total death of over 6.5 million since its outbreak in December 2019. Since then many therapeutic options have been approached and tested in clinical trials as well to find a potential cure or preventive therapy for the COVID-19 disease. This review summarizes the potential therapeutic options currently available for the treatment of COVID-19 including lopinavir-ritonavir, Hydroxychloroquine, Remdesivir, Ribavirin, dexamethasone, interferon, antibodies, Tocilizumab, Azithromycin, Piperacillin-tazobactam, Moxifloxacin, Ivermectin, Nitazoxanide, Baricitinib, and Arbidol. This study briefly discusses the clinical trials and encompasses the dosage, efficacy, adverse drug reactions, and possible mechanism of action of the potential treatment candidate where applicable. The growing number of reported cases posits an exigent need for a suitable therapy for the prevention and cure of this disease. Therefore, the study aims to provide vital information on each drug to highlight the latest scientific research that could be helpful for better prevention/treatment of COVID-19 disease.

Page(s): 223-237

DOI: DOI not available

Published: Journal: Pakistan Journal of Science, Volume: 74, Issue: 3, Year: 2022

Keywords:

COVID19 , COVID19 , Therapeutic approaches , Mechanism of action , Antiviral Drugs

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