ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort | [Pakistan Journal of Medical Sciences • 2021]

Author(s):

1. Huseyin Alakus: Department of Surgical Oncology, Adiyaman University Faculty of Medicine, Adiyaman, Turkey,

2. Mustafa Kaya: Department of Surgical Oncology, Dr. Ersin Aslan Education & Research Hospital, Gaziantep, Turkey.

3. Hatice Ozer: Department of Pathology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

4. Hatice Reyhan Egilmez: Department of Pathology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

5. Kursat Karadayi: Department of Surgical Oncology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Abstract:

Objective: Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection. Methods: Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22. Results: High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters. Conclusion: Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining.

Page(s): 543-549

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 37, Issue: 2, Year: 2021

Keywords:

Stomach Neoplasms , rhoA GTPBinding Protein , ADAM10 Protein , Neoplasms

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