The effect of acute complicated appendicitis on liver function test | [Pakistan Journal of Medical Sciences • 2021]

Author(s):

1. Kulsoom MoulaBux: Department of General Surgery, Ward-3, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

2. Sughra Parveen: Department of General Surgery, Ward-3, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

3. Mazhar Iqbal: Department of General Surgery, Ward-3, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

4. Ayesha Mehboob: Department of General Surgery, Ward-3, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Abstract:

Objectives: To determine the diagnostic role of hyperbilirubinemia in acute appendicitis like suppurative and gangrenous appendicitis. Methods: This observational study was conducted at Ward-3, Jinnah Postgraduate Medical Center (JPMC), Karachi from 1st June 2019 to 1st June 2020. Males and females above 12 years of age were included. Serum liver function tests and leukocyte counts were carried out. Appendectomies were done, the operative ifndings and histopathology reports were noted. Hyperbilirubinemia was related with the stages of appendicitis. Results were analyzed by SPSS version 25. Results: There were one hundred twenty patients. Thirty-eight (31.66%) were females and eighty-two (68.33%) were males. Age range was 13 to 60 years. Ten patients (8.33%) were between 13 - 20 years, sixty ifve (54.16%) were 21 to 30 years, thirty (25%) were 31 - 40 years, ten (8.33%) were 41 - 50 years and five patients (4.17%) were above 50 years of age. Sixty-two (51.66%) patients had simple appendicitis and fiftyfour (45%) had complicated appendicitis like suppurative (26.66%) and (16.66%) gangrenous appendicitis. Negative appendectomy was found in four (3.33%). Hyperbilirubinemia was found (100%) in gangrenous, (94.12%) in suppurative and (12.3%) in catarrhal appendicitis. Enzymes like Alanine transaminase and Aspartate transaminase were raised (50%) in gangrenous, (50%) in suppurative and (9.67%) in catarrhal appendicitis. TLC was raised in 112 (96.55%) out of 116 patients and total leukocyte count was normal in negative appendectomies. Conclusions: It is concluded that hyperbilirubinemia is strong diagnostic predictor for complicated appendicitis.

Page(s): 351-354

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 37, Issue: 2, Year: 2021

Keywords:

Suppurative appendicitis , Hyperbilirubinemia , Gangrenous appendicitis

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