Author(s):
1. Muhammad Umer Sulehria:
University of Veterinary and Animal Sciences,Lahore, Pakistan
2. Syed Saleem Ahmad:
University of Veterinary and Animal Sciences,Lahore, Pakistan
3. Muhammad Ijaz:
University of Veterinary and Animal Sciences,Lahore, Pakistan
4. Muhammad Hassan Mushtaq:
University of Veterinary and Animal Sciences,Lahore, Pakistan
5. Asfand Yar Khan:
University of Veterinary and Animal Sciences,Lahore, Pakistan
Abstract:
This study was conducted with an aim to diagnose canine coronavirus (CCoV) and to determine the antiviral effect of an antimalarial drug chloroquine (CQ). A total of thirty (n = 30) PCR-confirmed CCoV positive dogs (Canis lupus familaris) were randomly selected and included in the study for the drug trial. These 30 dogs were further divided into two groups; A (control) & B (treatment) containing 15 dogs each. Blood samples were collected from every dog to study the hematobiochemical parameters, i.e., CBC, LFTs and RFTs during the course of the experiment. In group A, 5 out of 15 dogs recovered and remained alive while 10 died (mortality rate 66.7%). In group B, 10 out 15 dogs recovered and 5 out of 15 died during the course of this study (mortality rate 33.7%). CQ should be considered for treatment in CCoV as it has good antiviral activity against coronavirus in dogs. © 2023 Friends Science Publishers
Page(s):
426-430
Published:
Journal: International Journal of Agriculture and Biology, Volume: 29, Issue: 6, Year: 2023
Keywords:
PCR
,
Chloroquine
,
Dog
,
Antiviral
,
Clinical trial
,
Canine coronavirus
,
Invitro study
References:
References are not available for this document.
Citations
Citations are not available for this document.