A study was carried out to investigate the impact of treated effluents of Fertilizer Plant on seasonal variations in physico-chemical parameters of Adam Sohaba Distributory water at Ahmaddali, Sadiqabad. Water samples were collected and analyzed on monthly basis for the period of ten months. Results indicated that air and water temperatures, light penetration and photoperiod showed higher values in summer than winter season. The values of turbidity, boiling point, pH, dissolved O2, acidity, alkalinity,residual sodium carbonates were decreased in mixed water as compared to distributory water in almost all months while the values of viscosity, surface tension, conductivity, free CO2, carbonates, bicarbonates, total hardness, total solids, total volatile solids, total dissolved solids, total volatile dissolved solids, sodium, calcium, magnesium, chlorides and sodium adsorption ratio were slightly increased in mixed water indicating the effect of treated industrial effluents. The monitored parameters were compared with water quality standards and most of them were found to be in the permissible limits indicating the proper functioning of wastewater treatment plant. The comparative study of Adam Sohaba Distributory water before and after mixing the treated effluents revealed that there was slight difference in water quality parameters. On the other hand, overall water quality parameters varied significantly which may be due to addition of urban wastes.