The Effcacy of an Initial Prednisone Monotherapy Regimen on PLA2R-associated Idiopathic Membranous Nephropathy | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2022]

Author(s):

1. Yu Bai: Department of Nephrology, Beijing Friendship Hospital, Capital Medical University,Beijing,China

2. Jing Liu: Department of Nephrology, Beijing Friendship Hospital, Capital Medical University,Beijing,China

3. Yajuan Duan: Department of Nephrology, Beijing Friendship Hospital, Capital Medical University,Beijing,China

4. Wenhu Liu: Department of Nephrology, Beijing Friendship Hospital, Capital Medical University,Beijing,China

5. Zongli Diao: Department of Nephrology, Beijing Friendship Hospital, Capital Medical University,Beijing,China

Abstract:

The aim of this study was to evaluate the e cacy and safety of prednisone monotherapy for phospholipase A2 receptor (PLA2R)-associated idiopathic membranous nephropathy (IMN). This was a retrospective cohort study involving 32 patients enrolled between January 2017 and June 2019 at Beijing Friendship Hospital, Capital Medical University, Beijing, China. Seventeen patients received prednisone monotherapy, and 15 received the Ponticelli regimen. The primary outcome was nephrotic syndrome remission at 1t2h month. The secondary outcomes were the incidence of adverse events and recurrence over the 12-month follow-up. At 1 2th month, 16/17 patients (94.1%) in the prednisone monotherapy group and 14/15 patients (93.3%) in the Ponticelli regimen group achieved remission (p = 0.19). The adverse events occurred in 9/17 and 9/15 of the patients receiving prednisone monotherapy and the Ponticelli regimen, respectively (p = 0.74). Four and three patients relapsed in the prednisone monotherapy and Ponticelli regimen groups, respectively (p = 0.99). Initial prednisone monotherapy had similar e cacy and safety compared with the Ponticelli regimen for PLA2R-associated IMN.

Page(s): 404-406

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 3, Year: 2022

Keywords:

PLA2Rassociated idiopathic membranous nephropathy , Prednisone monotherapy , Ponticelli regimen

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