Thyroid function in mothers who gave birth to neonates with transient congenital hypothyroidism. | [Pakistan Journal of Medical Sciences • 2009]

Author(s):

1. Gholamreza Asadi Karam: Department of Biochemistry and Biophysic, Faculty of Medicine, Rafsanjan, Tehran, Iran

2. Abdollah Gafarzadeh: Rafsanjan Medical University, Faculty of Medicine, Rafsanjan, Iran

3. Hamid Hakimi: Rafsanjan Medical University, Faculty of Medicine, Rafsanjan, Iran

4. Mohammad Khaksari: Department of Physiology and Pharmacology, Faculty of Medicine, Kerman University of Medical Sciences, Tehran, Iran

5. Hamidreza Rashidinejad: Internal Medicine, Physiology and Pharmacology, Faculty of Medicine, Rafsanjan, Iran

6. Mohsen Rezaeian: Social Medicine Department, Medical Faculty, Rafsanjan Medical School, Iran

Abstract:

Objective: To determine the thyroid status of mother’s of newborns with primary congenital hypothyroidism. Methodology: Thyroid function tests were carried out on 80 mothers of hypothyroid newborns and 80 mothers of non-hypothyroid newborns as control. Results: The mean difference of the tests revealed that mothers of congenitally hypothyroid infants had a lower triiodothyronine resin uptake (T3RU) concentrations compared with the control population. The higher value of free thyroxin index (FTI) in case group showed a tendency to significance. The proportional frequency distribution showed; T3RU and triiodothyronine (T3) had a significant difference, and FTI showed a tendency to significance. There were no significant differences between; thyroid-stimulating hormone (TSH), thyroxine (T4) and anti-thyroid peroxidase antibodies (anti-TPO) in two groups. Conclusionsn:: These results indicated that at least some cases of primary congenital hypothyroidism were attributable to the maternal thyroid disease. Therefore, we recommend that each pregnant woman should be assessed for thyroid function in region with a high prevalence of thyroid disease.

Page(s): 568-572

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 25, Issue: 4, Year: 2009

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