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Variations of serum lipids and proteins in renal diseases.
Author(s):
1. Akhtar Hussain Makhdoom: Department of Biochemistry, Sindh Medical College, Karachi, Pakistan
2. Mohammad Ashfaq Ali: Department of Biochemistry, Sindh Medical College, Karachi, Pakistan
3. Khem. A. Karira: Department of Biochemistry, BMIS, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
4. Rashid Qasim: Department of Biochemistry, Baqai Medical University, Karachi, Pakistan
Abstract:
BACKGROUND: Lipid abnormalities are frequently found in renal diseases. Experimental and clinical studies have demonstrated a positive relationship between, hyperlipidemia and rate of progression of renal disease, suggesting that lipids can induce or aggravate glomerular injury. In addition elevated plasma lipids can lead to atherosclerosis. OBJECTIVE: The present study proposes to observe the changes in the lipid levels in different renal diseases and to establish relationship between serum albumin and lipids levels in these different renal diseases. METHODS: Fifty nine patients and twenty one control subjects were selected for the study. The subjects were evaluated for renal function assessment and their serum protein and lipids were estimated and correlated. RESULTS: Serum urea, creatinine, total lipids, triglycerides and cholesterol were significantly high while serum total protein and albumin were significantly low in renal disease patients as compared to control subjects. No significant correlation was observed for serum albumin either with triglycerides or total cholesterol in any of the patients group. CONCLUSION: Renal diseases are associated with hyperlipidemia, hypercholestrolemia and hypertriglyceridemia with no significant correlation with hypoalbuminemia.
Page(s): 22-25
DOI: DOI not available
Published: Journal: Medical Channel: Journal of Modern Dental and Medical Sciences, Volume: 11, Issue: 1, Year: 2005
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