Use of the Systemic Immune-In ammation Index to Predict Treatment E cacy in Patients with Bladder Pain Syndrome | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2024]

Author(s):

1. Mehmet Fatih Sahin: Department of Urology, Tekirdag Namik Kemal University,Tekirdag,Turkiye

2. Esad Eseoglu: Department of Urology, Tekirdag Namik Kemal University,Tekirdag,Turkiye

3. Murat Akgul: Department of Urology, Tekirdag Namik Kemal University,Tekirdag,Turkiye

4. Arzu Malak: School of Health Nursing Department, Tekirdag Namik Kemal University,Tekirdag,Turkiye

5. Cagri Dogan: Department of Urology, Tekirdag Namik Kemal University,Tekirdag,Turkiye

6. Cenk Murat Yazici: Department of Urology, Tekirdag Namik Kemal University,Tekirdag,Turkiye

Abstract:

Objective: To determine the relationship between bladder pain syndrome (BPS) and systemic in ammatory index (SII) and to examine the impact of treatment protocols on it. Study Design: Observational Study. Place and Duration of the Study: Department of Urology, Tekirdag Namik Kemal University, Tekirdag, Turkiye, from January 2017 to December 2022. Methodology: A retrospective analysis was conducted on 30 BPS patients who underwent medical therapy. Upon diagnosis, the patients completed the king's health questionnaire (KHQ), beck depression questionnaire (BDQ), beck anxiety questionnaire (BAQ), and short form (SF-36) quality of life form. Peripheral blood SII was measured. After six months of regular therapy, the SII was recalculated when the patients completed the same forms again. The SII was compared between instances when patients reported more complaints, higher form scores, and instances when they reported fewer and lower scores. Results: The patients had a mean age of 46.1 ± 13.6 years, with four males and 26 females. The mean follow-up duration was 76.3 ± 24.5 months. Five patients of KHQ subcategories showed statistically signi cant decreases following therapy (52 to 39.17, 66.66 to 54.16, 54.40 to 41.07, 75.55 to 58.14, and 60.55 to 40.47). All patients of SF-36 components increased (p = 779, p = 0.393, p = 0.007, p = 0.004, p = 0.008, p = 0.041, p = 0.010, and p = 0.767, respectively). BDQ and BAQ decreased after therapy (11.55 to 11.41 and 11.86 to 11.24, respectively). Lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII decreased signi cantly (p = 0.001, 0.019, 0.002 and 0.039, respectively). Conclusion: SII, lymphocyte count, NLR, and PLR decreased after treatment, similar to BDQ and BAQ. SII is a simple and feasible method for evaluating the treatment e cacy of BPS.

Page(s): 556-560

DOI: 10.29271/jcpsp

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 34, Issue: 5, Year: 2024

Keywords:

Neutrophil , Platelet , Lymphocyte , Systemic immune in ammation index , Bladder pain syndrome

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