Author(s):
1. Sura Ali AL-ASADI:
Radiological Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU),Iraq
2. Muhammed Mizher RADHI:
Radiological Techniques Department, Health and Medical Technology College-Baghdad,
Middle Technical University (MTU), Iraq
3. Wisam Hindawi HOIDY:
Department of Chemistry, College of Education, University of Al-Qadisiyah,Al-Qadisiyah city,Iraq
Abstract:
The cyclic voltammetric electrochemical technique was utilized to investigate the effect of different temperatures on the redox current peaks of rifampicin (RF), a drug commonly used to treat many diseases including tuberculosis (TB), in vitro for human blood medium. A modified working electrode of glassy carbon electrode (GCE) with carbon nanotube (CNT) (CNT / GCE) was used as a sensitive nano-sensor to evaluate the impact of temperature on the blood medium in the presence of RF ions. The results confirmed the presence of two oxidation and one reduction current peaks of RF in blood medium at 0.5, 1, and -0.5 V respectively. The redox current peaks of RF ions in blood medium were enhanced with increasing the temperature from 20 to 36oC. The activation energy (E*) values were determined by applying Arrhenius equation with oxidative and anti-oxidative peaks of Ea*(Ipa)= 9.252 and 11.026 kJ.mol-1.K-1,respectively. Other thermodynamic functions such as the change in each of activation Enthalpy (?H*), activation Gibbs energy (?G*) and activation Entropy (?S*) values were estimated using Eyring equation. The present results of the effects of different temperatures on the blood status in presence of RF lead to the explanation of the oxidative stress of the drug which used in an inflammatory of blood at different temperature.
Page(s):
41-45
DOI:
DOI not available
Published:
Journal: Journal of Chemical Society of Pakistan, Volume: 43, Issue: 1, Year: 2021
Keywords:
Cyclic voltammetry technique
,
Rifampicin
,
Different temperature
,
Nanosensor
,
Blood medium
References:
References are not available for this document.
Citations
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