A Mesoporous Silica-Based Nano-Drug Co-Delivery System with Gemcitabine for Targeted Therapy of Pancreatic Cancer | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2024]

Author(s):

1. Quan Lin: Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University,Wenzhou, Zhejiang,China

2. Shiwei Guan: Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University,Wenzhou, Zhejiang,China

3. Minghui Peng: Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University,Wenzhou, Zhejiang,China

4. Haibo Yu: Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University,Wenzhou, Zhejiang,China

Abstract:

Objective: To investigate the e cacy and safety of the mesoporous silica-based nano-drug co-delivery system with gemcitabine (GEM) in the treatment of pancreatic cancer. Study Design: Experimental study. Place and Duration of the Study: Wenzhou Central Hospital, Zhejiang Province, China, between July 2022 and November 2023. Methodology: Ce6@MSN-Fe3O4/GEM@DPM nanoparticles were prepared and structurally characterised, then their drug loading and entrapment e ciency were calculated, and in vitro drug release and cytotoxicity assays were performed. In addition to that, mesoporous silica nanorods were prepared and structurally characterised for cellular uptake, cytotoxicity, and reactive oxygen species detection. Results: The mesoporous silica nanoparticles were spherical in shape and possessed a unique core-shell structure. The prepared nanoparticles had good entrapment e ciency and drug loading, and exibited pharmacotoxic and phototoxic e ects on cells. The mesoporous silica nanorods were taken up by pancreatic cancer cells and exbitied cytotoxicity. Conclusion: Mesoporous silica-based nano-drug co-delivery system, which carries GEM, is an e ective targeted drug delivery system to provide new research ideas for the treatment of pancreatic cancer.

Page(s): 1456-1463

DOI: 10.29271/jcpsp.2024.12.1456

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 34, Issue: 12, Year: 2024

Keywords:

Pancreatic cancer , Photodynamic therapy , Gemcitabine , Targeted drug delivery , Magnetic nanocomposites

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