Thoracic Radiotherapy E ect on the Outcome in Extensive Stage Small Cell Lung Cancer | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2023]

Author(s):

1. Ayse Kotek Sedef: Department of Radiation Oncology, Ersin Arslan Training and Research Hospital, Gaziantep, Turkey

2. Berna Akkus Yildirim: Department of Radiation Oncology, Baskent University Medical School, Adana, Turkey

3. Ahmet Taner Sumbul: Department of Medical Oncology, Baskent University Medical School, Adana, Turkey

4. Ozgur Ozyilkan: Department of Medical Oncology, Baskent University Medical School, Adana, Turkey

Abstract:

Objective: To evaluate the e cacy of thoracic radiotherapy to primary site in patients with extensive stage small cell lung cancer (SCLC) who had responded completely to systemic chemotherapy. Study Design: Observational study. Place and Duration of Study: Departments of Radiation and Medical Oncology, Baskent University and Dr. Ersin Arslan Research and Training Hospital in Turkey, between the years of 2011 and 2020. Methodology: The study included 125 patients with extensive stage SCLC. Demographic data and outcomes of chemotherapy and radiotherapy were collected. The e cacy of thoracic radiotherapy to primary site was evaluated in patients who had responded completely to systemic chemotherapy, in terms of progression-free survival and overall survival (OS). Results: The median follow-up time was 12 months and 98 (78.4%) patients died during follow-up. Seventy-three (58.4%) patients had complete response. Progression-free survival (PFS) for complete responder patients was 8 months, and OS for the whole group was found 13 months. Twenty (16%) patients received thoracic radiotherapy to primary site after complete response to platinum etoposide combination treatment. Patients receiving thoracic radiotherapy had better OS than those who did not (19versus 12 months respectively and p=0.002). Patients receiving thoracic radiotherapy had better PFS than those who did not (11versus 8 months, respectively, and p=0.01). Conclusion: Thoracic radiotherapy to primary site may improve the survival outcomes in extensive stage SCLC patients who had complete response to initial systemic chemotherapy.

Page(s): 188-192

DOI: 10.29271/jcpsp.2023.02.188

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 33, Issue: 2, Year: 2023

Keywords:

Outcomes , Lung cancer , Small cell lung cancer , Complete response , Thoracic radiotherapy

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views