Abstract:
Maternal obesity, which can be seen as a cycle spanning multiple generations, is an important factor linked to cognitive impairments. Recent research has revealed that Elateriospermum tapos (E. tapos) contains bioactive compounds that can alleviate cognitive decline. Yoghurt serves as a convenient medium to supplement obese maternal rats with E. tapos extract. The aim of this study is to investigate the impact of E. tapos in yoghurt on the cognitive function of maternally obese rats fed a high-fat diet (HFD). In this study, a total of 48 female Sprague-Dawley rats were used. These rats were fed an HFD for 16 weeks to induce obesity, and subsequently allowed to mate. Once pregnancy was confirmed, the obese rats were administered varying doses of E. tapos yoghurt (5, 50, and 500 mg/kg) until postnatal (PND) day 21. On PND 21, the maternal rats` body mass index (BMI), and oxidative status were assessed. Behavioral tests focusing on memory (open field and object recognition test) were conducted on PND 21.The results demonstrate that the groups supplemented with 50 and 500 mg/kg of E. tapos yoghurt exhibited similar BMI, ferric reducing ability of plasma (FRAP), and glutathione (GSH) levels, as well as a comparable recognition index when compared to the control group receiving saline supplementation. In conclusion, this study`s findings suggest that the formulated E. tapos yoghurt can act as an anti-obesity agent in maternal obesity and enhance memory dependent on the hippocampus.
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Published:
Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023