Abstract:
The current investigation was designed to study the changes of lipid profile in hypothyroid patients in local population and to investigate the importance of thyroid profile in old age dyslipidemic patients. Ninety-five newly diagnosed untreated hypothyroid patients (aged 49.21 ± 12.47 years, BMI 30.36 ± 5.8, 74 females and 21 males) were identified from thyroid OPD of Atomic Energy Medical Center, JPMC, Karachi. Patients were compared with 78 control subjects (aged 48.80 ± 11.00 years. BMI 30.51 ± 04.70, 54 females and 24 males) matched by age and body mass index (BMI). Serum TSH, FT4 FT3. Triacylglcerol (TAG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured. Significantly increased levels of TC and LDL-C in overt hypothyroid patients were observed. No significant differences were found in HDL-C and TAG in overt hypothyroid patients as compared to the control group. Elevated that requires therapeutic intervention. The deranged lipid profiles in hypothyroidism cannot be corrected without the treatment for hypothyroidism in these patients. Therefore, all older patients referred for diagnosis and treatment of dyslipidemia should also be screened for hypothyroidism.
Page(s):
3-7
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Biochemistry and Molecular Biology , Volume: 36, Issue: 1, Year: 2003