Utilization and Decision-Making Accuracy on Antithrombotic Prophylaxis by Caprini and Padua Risk-Assessment Models for Predicting Venous Thromboembolism in Hospitalized Patients | [Journal of Pioneering Medical Sciences • 2025]

Author(s):

1. Ali Hamid Abdulhussein: Department of Clinical Pharmacy, University of Al-Ameed, College of Pharmacy, Karbala, Iraq

2. Furqan M. Abdulelah: Department of Clinical pharmacy, College of Pharmacy, Al-Naji University, Baghdad, Iraq

3. Dhulfiqar Nidhal Alhilali: Department of Clinical pharmacy, College of Pharmacy, Baghdad University, Baghdad, Iraq

4. Ahmed Zakaria Al Arajy: Department of Pharmacy, Al-Farabi University College, Baghdad, Iraq

5. Safa Fakher Al-Baidhani: Department of Pharmacy, Al-Farabi University College, Baghdad, Iraq

6. Laith G. Shareef: Department of Pharmacy, Al-Rasheed University College, Baghdad, Iraq

7. Adil Salim Owaid: Department of Pharmacy, Al-Rasheed University College, Baghdad, Iraq

Abstract:

Background: Risk-Assessment Models may not accurately predict Venous Thromboembolism (VTE). This study prospectively assessed the use and decision-making accuracy of the Caprini and Padua risk-assessment models for antithrombotic prophylaxis in predicting VTE. Methods: Prospective study was conducted on 1075 Baghdad Teaching Hospital patients from December 1, 2022, until January 1, 2024. All patients and the subgroup examined for RAM discrimination using baseline medical and demographic data. Assessing Caprini and Padua scores' sensitivity and specificity. We analyze each score using the ROC curve and AUC. Results: The study observed 37 VTE cases. Individuals with VTE events had a significantly higher mean age (±SD) of 60.62 (15.8), p = 0.001. VTE occurs in 54% of acutely infected and/or rheumatologic patients P 0.002. Survival time and event-free period mean was 83.099 days (95% CI: 81.877-84.322) for patients without thromboprophylaxis and 74.085 days for those utilizing it. The Caprini RAM predicted VTE with 0.652 AUC, lower than Padua's 0.724. The Caprini RAM had 54.1% sensitivity and 61.7% specificity, whereas the Padua prediction score had 97.3% and 36.0%. Conclusion: The Caprini scores and Padua Prediction Score may improve hospital patients' thromboembolic risk classification compared to current practice.

Page(s): 21-28

DOI: 10.47310/jpms2025140403

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 14, Issue: 4, Year: 2025

Keywords:

Thromboembolism , RiskAssessment Models , Padua Prediction Score , Caprini scores

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