Behaviour of 4-(p-tolyI)-5,6,7,8-tetrabromo 1(2H) phthalazinone towards some nucleophiles. | [Journal of Chemical Society of Pakistan • 1989]

Author(s):

1. A. A. El-Sawy: Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

2. S. G. Donia: Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

3. S. A. Essawy: Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

4. A. M. F. Eissa: Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

Abstract:

The reactivity of 4-(p-tolyl)-5,6,7,8-tetrabromo 1(2H) phthalazinone (I) which contains two reaction sites (C = 0 and C = N) was investigated for reaction with alkyl or aralkyl magnesium halide under Grignard reaction conditions. This work also deals with the synthesis of the chlorophthalazine (lll) via the interaction of the titled phthalazinone with POCI3/PCI5 mixture, the chloro derivative having chlorine atom activated by heteryl moiety. Therefore, nucleophilic substitution reaction took place readily with the chloro substrate. The structures assigned to the products are supported by IR and NMR spectra.

Page(s): 111-116

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 11, Issue: 2, Year: 1989

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