Author(s):
1. Syed Hani Abidi:
Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan
2. Khalid Ahmed:
Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan
3. Shahana Urooj Kazmi:
Dadabhoy Institute of Higher Education (DIHE),Karachi,Pakistan
Abstract:
Objective: To evaluate the antibacterial activity of Aspirin, Mefenamic acid and Acetaminophen against Pseudomonas aeruginosa and Staphylococcus epidermidis biofilms. Methods: The study was conducted AKU Karachi in collaboration with DIHE Karachi from March 2018 to December 2018.Quantitative spectrophotometric method was used to study the reduction and removal of the Pseudomonas aeruginosa and Staphylococcus epidermidis formed biofilms. Statistical tests were performed using Graph Pad Prism software. Results: Acetaminophen showed maximum biofilm reduction activity against the biofilms formed by Pseudomonas aeruginosa, and Staphylococcus epidermidis. Mefanamic acid showed maximum biofilm removal potential against Pseudomonas aeruginosa, while Aspirin and Mefanamic acid were equally effective in removing biofilms formed by Staphylococcus epidermidis as well. Conclusion: There is a continuous need to look for non-antibiotic agents for their potential antimicrobial and antibiofilm potential.
Page(s):
1493-1495
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Medical Association, Volume: 69, Issue: 10, Year: 2019
Keywords:
Mefenamic acid
,
P aeruginosa
,
S epidermidis biofilms
,
Aspirin
,
Acetaminophen
References:
References are not available for this document.
Citations
Citations are not available for this document.