Variability of point mutation rates in Campylobacter coli: Preliminary data and observations. | [Pakistan Veterinary Journal • 2014]

Author(s):

1. Anna Caroli: Department of Veterinary Medicine, University of Bari “Aldo Moro”, SP per Casamassima, Valenzano (Ba), Italy

2. Elena Circella: Department of Veterinary Medicine, University of Bari “Aldo Moro”, SP per Casamassima, Valenzano (Ba), Italy

3. Carlo Pazzani: Department of Biology, University of Bari “Aldo Moro”, Via Orabona, 4, 70125 Bari, Italy

4. Antonio Camarda: Department of Veterinary Medicine, University of Bari “Aldo Moro”, SP per Casamassima, Valenzano (Ba), Italy

5. Marilisa Legretto: Department of Veterinary Medicine, University of Bari “Aldo Moro”, SP per Casamassima, Valenzano (Ba), Italy

6. Nicola Pugliese: Department of Veterinary Medicine, University of Bari “Aldo Moro”, SP per Casamassima, Valenzano (Ba), Italy

Abstract:

In this study we evaluated the in vitro variability of flaA in Campylobacter coli strains (Co19 and Co29) isolated from distinct poultry farms. Strains were characterized by flaA PCR-RFLP and subcultured in absence or presence of Salmonella enterica (S. Gallinarum) as a host competitor in poultry. Only transition mutations were detected and no flaA-flaB recombination events were observed. The highest ratio of flaA mutations was detected in the presence of competitor (1x10-6 and 4.8x10-6 for Co19 and Co29, respectively). While, transitions in absence of competitor were observed only in the strain Co29 (5.8x10-7). Data obtained in this investigation represent a preliminary study aimed to evaluate the possible linkage between specific haplotypes and their proneness to acquire point mutations which in turn might help strains to gain a better fitness for survival within and outside hosts.

Page(s): 243-246

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 34, Issue: 2, Year: 2014

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