Amphotericin B Induced Hypokalemia in a Diabetic Patient with Rhino-orbitocerebral Mucormycosis. | [Anaesthesia, Pain and Intensive Care • 2017]

Author(s):

1. Rajeev Sharma: Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India

2. Sushmita Bairagi: Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India

3. Sashmita Das: Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India

4. Jyotika Kumar: Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India

Abstract:

Rhino-orbito-cerebral mucormycosis is an aggressive and potentially lethal invasive fungal infection. Surgical debridement and amphotericin B remain the mainstay of treatment, however, associated side effects of amphotericin B like nephrotoxicity, hypokalemia, hypertension and arrhythmias need to be addressed. We discuss the anesthetic management of a 47 year old male with uncontrolled diabetes diagnosed with left sinoorbital mucormycosis posted for surgical debridement. The patient received amphotericin B and insulin preoperatively. Nephrotoxicity due to amphotericin B led to hypokalemia in this patient. We also discuss the role of liposomal formulation in preventing hypokalemia and other side effects associated with use of amphotericin.

Page(s): 90-93

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 21, Issue: 1, Year: 2017

Keywords:

Keywords are not available for this article.

References:

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