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Acylhydrazide schiff bases: synthesis and antiglycation activity.
Author(s):
1. Khalid Mohammed Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
2. Muhammad Taha: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia
3. Fazal Rahim: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Department of Chemistry, Hazara University, Mansehra, Pakistan
4. Muhammad Imran Fakhri: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
5. Waqas Jamil: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Institute of Advance Research Studies in Chemical Sciences, University of Sindh, Pakistan
6. Momin Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Department of Chemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan
7. Saima Rasheed: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
8. Aneela Karim: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
9. Shahnaz Perveen: PCSIR Laboratories Complex Karachi, Karachi, Pakistan
10. Mohammad Iqbal Choudhary: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Abstract:
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 µM), 27 (IC50 = 234.83 ± 10.28 µM), 2 (IC50 = 240.99 ± 4.2 µM), and 14 (IC50 = 276.2 ± 2.3 µM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 µM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.
Page(s): 930-938
DOI: DOI not available
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 35, Issue: 3, Year: 2013
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