The role of vitamin D supplementation in augmenting IFN-γ production in response to mycobacterium tuberculosis Infection: A randomized controlled trial | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Muhammad Imran Hussain: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

2. Ramisha Ibtisam: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

3. Tayyaba Fatima: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

4. Huba Khalid: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

5. Ayesha Aziz: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

6. Khansa: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

7. Adan Sitara: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

8. Anam Shahzad: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

9. Aymen Jabeen: Department of Allied Health Science, Nutrition and Dietetics, Riphah Unternational University,Lahore,Pakistan

Abstract:

Vitamin D supports the immune system fight TB by inhibiting Interferon-gamma (IFN-?) and lowering host inflammation. The purpose of the research was to see if giving the vitamin D supplements to TB patients affected their prognosis. A randomized placebo control study of 200 TB patients was performed among which 106 received 400,000 IU of injectable vitamin D3 and 94 received placebo for 2 doses. Assessment was carried out at the end of every month for 3 months. IFN-? responses to whole blood stimulation generated by the Mycobacterium tuberculosis sonicate (MTBs) antigen and early secreted and T cell activated 6 kDa (ESAT6) were assessed at 0 and 12 weeks. The statistical analysis used descriptive statistics (mean and standard deviation), Friedman's test and Fisher's test. The vitamin D group gained significantly more weight (+3.90 pounds) and had less persistent lung disease on imaging (1.33 zones vs. 1.84 zones). They also had a 50% decrease in cavity size. Additionally, patients with low baseline serum concentrations of 25-(OH)D had a significant increase in MTB-induced IFN-? production after taking vitamin D supplements. Vitamin D administration in large amounts can hasten the recovery of TB patients. The findings point is a therapeutically useful activity of Vitamin D's in the management for tuberculosis.

Page(s): 1901-1908

DOI: 10.36721/PJPS.2023.36.6.SP.1901-1908.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: S6, Year: 2023

Keywords:

Tuberculosis , Vitamin D , Infection , Protein , interferon gamma

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