Abstract:
Objective To examine the relationship between transforming growth factor (TGF)-ß with recurrent erythema nodosum leprosum (ENL) based on the anti-phenolic glycolipid (PGL)-1 IgM antibody and cortisol in leprosy patients. Results There were 22 subjects with recurrent ENL reaction (16 male, 6 female, mean age 34.9 year). Mean TGF-ß was 62.6 ± 30.4 pg/ml, the IgM anti PGL-1 was 2029 ±1687 µg/ml, and the cortisol was 6.61 ± 1.99 µg/dl, and 22 subjects nonrecurring reaction as controls (15 male, 7 female, mean age 47 year) the mean of TGF-ß level was 47.2 ± 23 pg/ml, anti PGL-1 IgM antibody was 629 ±1043 µg/ml and the cortisol was 5.07 ± 2.01 µg/dl. The t-independent statistic test the influence of leprosy MB type group to the recurrent ENL reaction and the un-recurrent ENL patients to TGF-ß, IgM anti-PGL-1 and cortisol had p value = 0.015, 0.001 and 0.035 (p <0.05), respectively implying significant difference between subjects and controls. The result of logistic binary test of TGF-ß, IgM anti-PGL-1 and cortisol was 0.25, 0.016 and 0.771. This means that IgM anti-PGL-1 has correlation as variable of TGF-ß with recurrent ENL. Conclusion There was significant difference between the levels of TGF-ß, anti-PGL-1 IgM antibody and cortisol in leprosy patients with the recurrent ENL reaction and those with nonrecurring ENL reaction. There was a correlation between the levels of TGF-ß with recurrent ENL based on the IgM anti-PGL-1. The increasing levels of TGF-ß and IgM anti-PGL-1 level on patients with leprosy MB type can be a predictor of the recurrent reaction.
Page(s):
10-16
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Association of Dermatologists, Volume: 28, Issue: 1, Year: 2018
Keywords:
Leprosy
,
TGFß
,
IgM antiPGL1
,
cortisol
,
erythema nodosum leprosum