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The Comparison of the Effects of Platelet Rich Plasma and Streptokinase on Intra-Abdominal Adhesion: In the Rat Cecum Model
Author(s):
1. Hanifi Erol: Deparment of Surgery, Faculty of Veterinary Medicine, University of Erciyes,Kayseri,Turkey
2. Esra Balcıoğlu: Department of Histology and Embryology, Faculty of Medicine, Erciyes University,Kayseri,Turkey
3. Fadime Daldaban: Department of Genetics, Faculty of Veterinary Medicine, University of Erciyes,,Turkey
4. Korhan Arslan: Department of Genetics, Faculty of Veterinary Medicine, University of Erciyes,,Turkey
5. Yunus Dönder: Deparment of Surgery, Kayseri City Education and Research Hospital, University of Sağlık Bilimleri,Kayseri,Turkey
6. Bilal Akyüz: Department of Genetics, Faculty of Veterinary Medicine, University of Erciyes,,Turkey
Abstract:
This study aimed to investigate the effects of platelet rich plasma (PRP) and streptokinase (SK) on postoperative intra-abdominal adhesion formation in rats. The 4-month-old, healthy, non-pregnant female Wistar-Albino rats were used as animal material. The remaining 24 animals were divided into three groups with 8 rats in each group (PRP, SK and Control). The fibroblast proliferation, mononuclear cell infiltration and giant cells were clearly prominent in control group. A decrease was observed in the ratio of these cells in the PRP and SK groups. The comparison of the expression levels of vWF, CASP3 and IL-6 genes showed that the vWF gene was downregulated in the SK group and the IL-6 gene was downregulated in the PRP and SK groups. They were statistically significantly compared to the control group. It was concluded that the expression level of CASP3 gene decreased in the PRP and SK groups compared to the control group, but this decrease was not statistically significant. The PRP and SK could be applied intraperitoneal to prevent the adhesions after intra-abdominal surgery.
Page(s): 794-802
Published: Journal: Pakistan Veterinary Journal, Volume: 44, Issue: 3, Year: 2024
Keywords:
Adhesion Cecum PRP SK Rat
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