A prospective, randomized, double-blind, comparative study of the efficacy of intravenous ondansetron and palonosetron for prevention of postoperative nausea and vomiting. | [Anaesthesia, Pain and Intensive Care • 2013]

Author(s):

1. Bijaya Kumar Shadangi: Department of Anesthesiology, Medanta-Medicity, Gurgaon, Sector-38, Delhi-NCR, India

2. Jitendra Agrawal: Department of Anesthesiology, GR Medical College, Gwalior, India

3. Rabindra Pandey: Department of Anesthesiology, All India Institute of Medical Sciences, New Delhi, India

4. Arvind Kumar: Department of Anesthesiology, Medanta-Medicity, Gurgaon, Sector-38, Delhi-NCR, India

5. Sanjay Jain: Department of Anesthesiology, GR Medical College, Gwalior, India

6. Rakhi Mittal: Department of Anesthesiology, GR Medical College, Gwalior, India

7. H K Chorasia: Department of Anesthesiology, GR Medical College, Gwalior, India

Abstract:

Background: Palonosetron is a second generation 5-Hydroxytryptamine-3 receptor antagonist with longer halflife and higher receptor binding affinity than Ondansetron. Aims & objective: To assess the efficacy and safety profile of intravenous palonosetron cpompared to the ondansetron for prevention of post-operative nausea and vomiting (PONV) under general anesthesia. Methodology: A prospective, randomized, placebo-controlled, double-blind study was conducted in 90 patients aged 20-60 years, undergoing major surgeries. Group I (n=30) received placebo injection; Group II (n=30) received inj. ondansetron 8 mg and Group III (n=30) received inj. palonosetron 0.075 mg IV. In the operating room, the study drugs were given IV in equal volume of 4ml, before inducing the patients. In postoperative period each patient was observed for retching, nausea and/or vomiting at 30 min; and then at 1, 2, 6, 12 and 24 hours. Any side effects intra-operatively and post-operatively were recorded. Results: The number of patients, who remained vomiting free in the first 24 hours after surgery was 56.6%, 80% and 86% in the placebo, Ondansetron and Palonosetron groups respectively. The difference with placebo was highly significant for ondansetron (p

Page(s): 55-58

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 17, Issue: 1, Year: 2013

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