ASSOCIATION OF OBESITY WITH RAPID VIROLOGICAL RESPONSE IN PATIENTS WITH CHRONIC HEPATITIS C | [Journal of Postgraduate Medical Institute • 2017]

Author(s):

1. Moeen-Ul-Haq: Department of Gastroenterology, Lady Reading Hospital, Peshawar - Pakistan

2. Muhammad Kamran Hassan: Department of Gastroenterology, Lady Reading Hospital, Peshawar - Pakistan

3. Ahmad Nawaz Babar: Department of Gastroenterology, Lady Reading Hospital, Peshawar - Pakistan

4. Aamir Ghafoor Khan: Department of Gastroenterology, Lady Reading Hospital, Peshawar - Pakistan

Abstract:

Objective: To determine the association of obesity with rapid virological response in patients with chronic hepatitis C on antiviral therapy. Methodology: In this prospective cohort study patients suffering from chronic hepatitis C who required treatment were included after getting ethical approval and informed consent. Patient's weight and height was measured and body mass index (BMI) was calculated. Patients were divided into 2 groups; group 1 having BMI 30 in equal numbers. All the patients were put on weekly pegylated interferon plus ribavirin in fixed divided doses. PCR was done at the completion of 4 week to check for rapid virological response (RVR). After completion of study these 2 groups were compared to see whether any significant association exists between BMI and RVR. RVR was also stratified among age, viral load and gender to see their effect as these are potential effect modifiers. Results: There were 140 (56.3 %) male and 110 (43.7%) female patients with male to female ratio of 1.2:1. Mean age of the patients was 39.78 ±9.85, while mean BMI was 27.40 ±5.86. Overall the RVR was achieved in 53.2% of the patients. Frequency of RVR was 77(61.6 %) in non-obese patients as compared to 56(44.8%) in obese patients with a p value of 0.008. Conclusion: Obesity is significantly associated with poor RVR in patients with chronic hepatitis C.

Page(s): 44-50

DOI: DOI not available

Published: Journal: Journal of Postgraduate Medical Institute, Volume: 31, Issue: 1, Year: 2017

Keywords:

Body mass index , Obesity , hepatitis C , Rapid virological response

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