Analgesic and Anti-inflammatory Potential in Misopates orontium | [Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences • 2020]

Author(s):

1. Muhammad Ajaib: Department of Botany, Mirpur University of Science and Technology (MUST),Mirpur- (AJK),Pakistan

2. Zel-E-Arooj: Department of Botany, Mirpur University of Science and Technology (MUST),Mirpur- (AJK),Pakistan

3. Khalid Mohammed Khan: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-, Pakistan;Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box, Dammam, Saudi Arabia

4. Kanwal: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi,Karachi-,Pakistan

5. Shahnaz Perveen: PCSIR Laboratories Complex,Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi-,Pakistan

6. Shazia Shah: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi,Karachi-,Pakistan

Abstract:

The Misopates orontium (L.) Raf has been reported for its medicinal importance in the literature. This plant has been studied for its antioxidant and hepatoprotective studies. In the current study the in vitro analgesic and antiinflammatory potentials of ethanol extracts of an ethnomedicinal plant Misopates orontium (L.) Raf was evaluated in a dose-dependent manner. The analgesic activity was determined via hot plate, tail flicking/immersion methods, and paw licking in mice, whereas, the anti-inflammatory potential was investigated by using carrageenan-induced hind paw edema in albino rats. The doses of 100, 200, and 300 mg/kg concentrations were used. The extract of 300 mg/kg displayed significant results within the range of 22.4 ± 0.79 and 7.2 ± 0.83 at 1.5 h for hot plate and tail immersion methods, respectively, in comparison with the standard drug aspirin. In the paw licking method the most effective dose was 300 mg/kg at which the licking and biting were reduced within 30 minutes, i.e. 3 ± 0.58 at 10 min. In the anti-inflammatory activity, the expansion in paw volume was measured after carrageenan injection. Results indicated that after carrageenan injection the paw volume increased but after a few intervals of time, it again reduced, i.e. 6.17 ± 0.15 at 2 h as compared to standard drug diclofenac sodium. This study reveals the anti-inflammatory and analgesic efectiveness of this plant, as it is also used locally to reduce pain and inflammations. Further studies on the isolation of active metabolites from the ethanol extract of M. orontium may lead to the discovery of new and novel molecules which can be used as drug candidates.

Page(s): 69-74

DOI: DOI not available

Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 57, Issue: 1, Year: 2020

Keywords:

Antiinflammatory , analgesic , Aspirin , Misopates orontium L , Raf , diclofenac sodium

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