A randomized Controlled Study on Prevention of Succinylcholine Induced Fasciculation and Myalgia by Pretreatment with Pregabalin in Patients Undergoing Laparoscopic Cholecystectomy. | [Anaesthesia, Pain and Intensive Care • 2017]

Author(s):

1. Muhammad Amjad Khan: Department of Anesthesiology & Intensive Care, FMH College of Medicine & Dentistry /Fatima Memorial Hospital, Shadman, Lahore (Pakistan)

2. Khalid Javid Siddiqi: Department of Anesthesiology & Intensive Care, FMH College of Medicine & Dentistry /Fatima Memorial Hospital, Shadman, Lahore (Pakistan)

3. Khalid Mahmood Anjum: FMH College of Medicine & Dentistry /Fatima Memorial Hospital, Shadman, Lahore, Pakistan

4. Ameer Hamza: Department of Anesthesiology & Intensive Care, FMH College of Medicine & Dentistry /Fatima Memorial Hospital, Shadman, Lahore (Pakistan)

Abstract:

Introduction: Fasciculation and myalgia are the two most common and distressing 4Medical Oficer side effects of succinylcholine administration. Many drugs have been tried to prevent D&eIpnatertnmsievnetCoafrAe,nFeMstheHsiCoolollgeyge or reduce this unpleasant happening with variable success. In this comparative study, of Medicine & Dentistry /Fatima we evaluated the preventive effect of pregabalin on the occurrence of succinylcholine Memorial Hospital, Shadman, induced fasciculation and myalgia in patients undergoing laparoscopic cholecystectomy. Lahore (Pakistan) Methodology: This, randomized controlled trial, was done in operating rooms of a teaching hospital over a period of six months. 70 patients of either sex, of ASA physical tsatus 1 & 2, electively scheduled for laparoscopic cholecystectomy, were recruited for the study. Selected patients were divided into two groups with 35 patients in each group by lottery method of randomization. Study group - Group P received 150 mg of pregabalin orally two hours before anesthesia and Group C (control group) received placebo pills two hours before induction. Standard general anesthesia technique with succinylcholine as muscle relaxant at induction was used in all patients and incidence and severity of fasciculation at induction and postoperative myalgia were recorded in these patients. Results: All the patients completed the study. Incidence of fasciculation was not significantly lower in pregabalin group (p value 0.096). However, its severity was significantly reduced in Group P as compared to Group C (1 vs. 7 patients). Incidence and severity of postoperative myalgia was quite reduced in Group P vs. Group C (p value 0.000). Conclusion: Pretreatment with 150 mg of pregabalin two hours before anesthesia decreases the severity of succinylcholine induced fasciculation and reduces the incidence and severity of myalgia in patients undergoing laparoscopic cholecystectomy.

Page(s): 447-452

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 21, Issue: 4, Year: 2017

Keywords:

uccinylcholine , Fasciculation , Myalgia , Pregabalin , Laparoscopic cholecystectomy

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