Abstract:
A biotransformation is a key tool for the structural modification of natural and synthetic complex compounds. It is employed to synthesize those compounds, which are arduous to get from chemical synthesis. During the last few decades' research has been focused on the modification of biologically potent compounds. Biotransformation is one of the effective ways in this regard. The current article covers the biotransformation of norethisterone (1) by using various bacteria and fungi as well as metabolism in man and animals i.e. rat, rabbit, monkey and dog, which brought mono-, di-, and tri-hydroxylation, oxidation, reduction, epoxidation and deethynylation of 1. The review covers 26 metabolites (2 to 27) of 1, obtained during 1906 to 2018.
Page(s):
195-203
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Biotechnology, Volume: 17, Issue: 4, Year: 2020
Keywords:
bacteria
,
metabolites
,
fungi
,
human
,
Biotransformation
,
Norethisterone
,
Progestin