The effect of methyl palmitate on treatment of experimental asthma. | [Journal of Pakistan Medical Association • 2015]

Author(s):

1. Can Temiz: Department of Chest Diseases, Dokuz Eylul University, Izmir, Turkey

2. Serdar Kalemci: Department of Chest Diseases, Faculty of Medicine, Mugla University, Mugla, Turkey

3. Serap Cilaker Micili: Department of Histology, Dokuz Eylul University, Izmir, Turkey

4. Isil Tekmen: Department of Histology, Dokuz Eylul University, Izmir, Turkey

5. Gülserap Yildiz: Department of Biochemistry, Health Sciences Institute of Adnan Menderes University, Aydin, Turkey

6. Tolgahan Acar: Department of Anatomy, Faculty of Medicine, Sifa University, Izmir, Turkey

7. Sibel Ayik: Department of Chest Diseases, Katip Celebi University, Izmir, Turkey

8. Saliha Aksun: Department of Biochemistry, Facultyof Medicine, Katip Celebi University, Izmir, Turkey

9. Osman Yilmaz: Multidisciplinary Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

10. Atila Akkoclu: Department of Chest Diseases, Katip Celebi University, Izmir, Turkey

Abstract:

Objective: To determine the effects of methyl palmitate on murine model of chronic asthma. Methods: The experimental study was conducted in the animal laboratory of DokuzEylul University, Turkey, from October to December, 2012, and comprised BALB/c mice whowere divided into four equal groups: three experimental and one control group. All groups except the control group were sensitised and challenged with ovalbumin. Mice with experimentally-induced asthma in Group I received saline; Group II dexamethasone 1mg/kg; Group III methyl palmitate300mg/kg intraperitoneally three times per week in the last four weeks of the study period. Animals were sacrificed 24h after the last administration ofstudy drugs. Histological findings of airways were evaluated by light microscopic examination. Blood samples from vena cava inferior were taken for measurement of interleukin-5 levels. SPSS 15 was used for statistical analysis. Results: The 28 female mice in the study were divided into 4 groups of 7(25%) each. The age range of the animals was 6-8weeks, and the weight range was 18-20g. All histological parameters and interleukin-5 levels of asthma in the Group III were significantly ameliorated compared to the Group I (p

Page(s): 632-636

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 65, Issue: 6, Year: 2015

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