Abstract:
Objective: To investigate the possible relationship between TNF-a, Interleukin-6, NT-pro BNP, leptin and ferritin with echocardiography findings in thalassemia patients compared to controls. Methodology: This case control study was performed on patients and controls from 1st January to 31st December, 2017. Blood samples were taken from participants in fasting to measure Leptin, Ferritin, TNF-a, NT-pro BNP and IL-6 serums. Participants underwent echocardiography by pediatric cardiologist. The level of error considered as 0.05 for data analysis by SPSS version 20.0. Results: There were 112 cases and 114 controls. Mean age of participants was 16.09±7.11 years. NT-pro BNP, TNF-a, IL-6, and Ferritin were different in patients compared to control but leptin was same. Left DT was higher in patients. All echo modalities including A and E, doppler velocities, EF, FS, heart rate, left Peak E/A, right Peak E/A , LA/Ao in diastole, and in systole ,LVMI, MPI left, MPI right and BMI were different in patients and controls(p<0.05). In patients, NT-pro BNP, leptin, TNF-a, Interleukin and ferritin did not correlate to each other except TNF-a and IL-6(p=0.001). Conclusion: NT-pro BNP, TNF-a, IL-6, Ferritin were higher in cases and they correlated with some of echocardiography findings whereas leptin was same in case and controls and correlated with ECG findings only. The findings of the study suggested that NT-pro BNP maybe the best bio marker for evaluation of cardiac function in thalassemia patients.
Page(s):
14-26
DOI:
DOI not available
Published:
Journal: Pakistan Heart Journal, Volume: 52, Issue: 1, Year: 2019