The Pulmonate Limpet Siphonaria lessoni: Pharmacological Study of Norsiphonarienone, a Polipropionate | [Pakistan Veterinary Journal • 2017]

Author(s):

1. José L Martinez: Vicerrectory of Research, Development and Innovation, University of Santiago of Chile,

2. Juana Rovirosa: Faculty of Sciences, University of Chile,

3. Claudio Laurido: Faculty of Chemistry and Biology, University of Santiago of Chile,

4. Aurelio San Martin: Faculty of Sciences, University of Chile,

5. Raul Vinet: Faculty of Pharmacy, University of Valparaíso & CREAS-Valparaíso,Chile

6. Luisauris Jaimes: Faculty of Chemistry and Biology, University of Santiago of Chile,

Abstract:

We presented a marine natural product, norsiphonarienone, isolated from Siphonaria lessoni, a pulmonate limpet of Central Chile. The norsiphonarienone was pharmacologically studied in rat thoracic aorta with endothelium previously contracted with phenylephrine. This technique has been widely used to describe pharmacological characterization and seek for mechanisms of action of natural products and other physiological phenomena. The main characteristics described are pD2 (-log EC50) and maximum effect or maximal contraction (Emax). The results show that norsiphonarienone induced a significant difference in the maximal contraction and also in the pD2 (-log EC50).

Page(s): 482-484

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 37, Issue: 4, Year: 2017

Keywords:

Norsiphonarienone Pharmacological study Rat thoracic aorta Siphonaria lessoni

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