The diagnostic value of c-reactive protein estimation in differentiating bacterial from viral meningitis | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2001]

Author(s):

1. Azeem Sheikh: Department of Medicine, Shaikh Zayed Hospital, Lahore, Pakistan

Abstract:

To evaluate the efficacy of serum and CSF C-reactive protein (C-RP) in differentiating bacterial from viral meningitis. Design : An observational, prospective hospital-based study. Place and Duration of Study: it was conducted at the Department of Medicine and Department of Pediatrics, Shaikh Zayed Postgraduate Medical Institute, Lahore, over a period of one year between March, 1999 and March, 2000. Subjects and Methods: A randomized group of thirty patients, who presented with clinical features, suggestive of meningitis, were included in the study. C-reactive protein determinations were performed by Latex agglutination method on the serum and cerebrospinal fluid (CSF) of these patients. Results: In the present study, C-reactive protein was found to be a more sensitive test for differentiating bacterial from non-bacterial meningitis on initial examination than the usual conventional methods used to diagnose bacterial meningitis. CSF C-reactive protein had a greater sensitivity (92%) as compared to serum C-reactive protein (71 %). Conclusion: C-reactive protein determination in CSF was found to be a useful indicator of bacterial meningitis that can be used to distinguish it from viral meningitis.

Page(s): 622-624

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 11, Issue: 10, Year: 2001

Keywords:

Viral , CReactive Protein Cerebrospinal Fluid Meningitis Meningitis , Bacterial Meningitis

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