A retrospective large original study of cutaneous melanoma | [Pakistan Journal of Medical and Health Sciences • 2021]

Author(s):

1. HOJAT EFTEKHARI: Department of Dermatology, Guilan University of Medical Sciences,Rasht,Iran

2. SHABNAM FAHIM: Department of Dermatology, Pediatric Dermatology Fellowship, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

3. ZEINAB ARYANIAN: Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences,Tehran,Iran

4. AZADEH GOODARZI: Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences,Tehran,Iran

5. ALI SADEGHINIA: Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

6. PEDRAM NOURMOHAMMADPOUR: Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences,Tehran,Iran

7. MONIREH MAZANDARANI: Department of General Medicine, Shahroud University of Medical Sciences, Shahroud, Semnan, Iran;Golestan University of Medical Sciences, Sayad Shirazi Hospital, Gorgan, Iran

8. ALI POURALI: Department of General Medicine, Guilan University of Medical Sciences,Rasht, Guilan,Iran

9. SEPEHR KHOSRAVI: School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Universal Scientific Education and Research Network (USERN), Tehran, Iran

10. ZOHRE KHODASHENAS: Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences,Tehran,Iran

11. MAISA NOURALINEJAD: Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences,Tehran,Iran

Abstract:

Background: The incidence of cutaneous malignant melanoma (CMM) has increased continuously during recent decades among many populations of the world. Cutaneous Malignant Melanoma is a malignancy with a demographic and ethnic disparity located in the skin and mucous membranous. The objective of this study is to determine Cutaneous Melanoma (CM) characteristics in Iran. Methods: This is a retrospective cross sectional study. We used data from Razi Hospital, Tehran University Melanoma Cancer Registry. The cases included in this study met the following criteria: primary CM, in situ or invasive, diagnosed in the recent past ten years. We have evaluated prognostic factors in addition to basic demographic data. Result: A total of 193 melanomas (99 males (51.3%) and 94 females (48.7%)) were included. The mean age was 58.3±15.8years. The most frequent location for melanoma was lower extremity (75 patients, 38.9%). The most frequent subtype for melanoma based on histopathology was the Acral Lentiginous Melanoma (ALM) (74 patients, 38.3%). There was statistically significant difference between histological subtypes of melanoma and Breslow thickness (p? 0.00 1). Conclusion: Present study showed risk factors such as age and pre-existing nevus are important factors in CMM incidence in Iran. Early detection of melanoma is a key factor in improving patients' survival.

Page(s): 1995-1998

DOI: 10.53350/pjmhs211561995

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 15, Issue: 6, Year: 2021

Keywords:

Epidemiology , Histology , histopathology , cancer , Immunohistochemistry , IHC , Cutaneous Melanoma , Skin cancer , Original study , Malignant Melanoma

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