BOT-1964: Exploring pharmacological applications of Phytofabricated Zinc Oxide Nanoparticles | [4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025 • 2025]

Author(s):

1. Farah Saeed: RWU,Rawalpindi, Pakistan.

2. Banzeer Ahsan Abbasi: RWU,Rawalpindi, Pakistan.

3. Syeda Anber Zahra: Institute of Biomaterial & Biomedical, Shanghai Zhongqiao Vocational & Technical University.,Shangai,China

4. Javed Iqbal: BKU,Charsadda, Pakistan.

5. Shazia Rehman: RWU,Rawalpindi, Pakistan.

6. Mamoona Munir: RWU,Rawalpindi, Pakistan.

7. Hafsa Ansar: RWU,Rawalpindi, Pakistan.

8. Rabia Kazmi: RWU,Rawalpindi, Pakistan.

Abstract:

The vast applications and utilization of greenly synthesized nanoparticles atcommercial level have revolutionized nano-pharma industries due to enhancedbioavailability, and reduced toxicity. The nanodrugs delivery systems that areobtained from natural resources are more effective, soluble, safe and stable thanchemically derived nanosystems. Bioinspired nanomaterials obtained by greensynthesis including metal oxide or metal and hybrid nanoparticles areenvironment friendly, unharmful and safer to be employed in biomedicine. Thephyto-fabrication is ecofriendly, cheap and is a potential alternative to traditionalroutes for fabricating nanostructures. The current study involves fabrication ofLactuca polycephala mediated zinc oxide nanoparticles. The functional moietiesand green chemicals from Lactuca polycephala are believed to reduce salt usedfor the preparation of nanosized particles. The asynthesized green nanoparticleswere validated UV-Vis (Ultraviolet-Visible), XRD, SEM, FT-IR (Fouriertransforminfrared). The mean size of the L. polycephala sourced zinc oxidenanoparticles was found to be 18 nm. The significant bactericidal properties ofas-prepared NPs was recorded which was demonstrated using different bacterialstrains. The promising antifungal potency was reported for our L. polycephalasourced zinc oxide nanoparticles. Cytotoxicity assessment of L. polycephala-ZnONPs against nascent hatchling revealed concentration-dependent response.The synthesized green NPs revealed significant antioxidant potential confirmingthe attached reductones upon the surface/interface of ZnONPs. In conclusion,our greenly fabricated nanoparticles have shown significant in vitro biopotentials.In future, the mechanistic applications and devising of scalablemethods should be focused to fully explore the potential of L. polycephalasourced nanoparticles.

Page(s): 68-68

DOI: DOI not available

Published: Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025

Keywords:

antibacterial activities , antifungal activities , Antimicrobial activities , anticancer activity , L polycephalaZnONPs

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