A murine model of femoral artery injury: tricks of the trade. | [Pakistan Journal of Zoology • 2017]

Author(s):

1. Jixue Hou: Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, China,Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China

2. Xueling Chen: Department of Immunology, School of Medicine, Shihezi University,Shihezi, Xinjiang 832002,China

3. Jing Wang: Out-patient department, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

4. Hongwei Zhang: Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

5. Yu Xi: Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

6. Jie Xia: Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

7. Xinyu Peng: Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

8. Xiangwei Wu: Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University,Shihezi, Xinjiang,China, Laboratory of Translational Medicine, School of Medicine, Shihezi University,Shihezi, Xinjiang,China

Abstract:

Mammals is a powerful tool to study pathophysiologic process of cardiovascular disease, but for a long time it is just limited to large animals, like pigs, rabbits, and big rats. The mice with reproduction fast cycle, lower costing, and close to human genes, can be showed about some phenomenon quickly, also more easy to form model of atherosclerosis. Thus, a mouse model of vascular injury is vitally important for researching the pathophysiological mechanisms to restenosis after percutaneous transluminal coronary angioplasty (PTCA) as well as translational approaches. In this Experiment, we established a unique murine model of femoral artery injury through a home-made wire. The mouse model of vascular injury may be used to explore the molecular mechanism of post-angioplasty restenosis with lowest costing.

Page(s): 505-508

DOI: 10.17582/journal.pjz/2017.49.2.505.508

Published: Journal: Pakistan Journal of Zoology, Volume: 49, Issue: 2, Year: 2017

Keywords:

Banna Minipig Inbred Line , Nucleoplasmin

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