Abstract:
One of the most significant health challenges that researchers and the pharmaceutical industry are working on is to prevent drug-induced renal disease, which is the result of direct nephrotoxicity. Nephrotoxicity occurs when kidney-detoxification and excretion do not work properly as there is a damage of kidney function by any endogenous or exogenous toxicants. Marine algae are found to be excellent in their nutritional and potential therapeutic properties. To investigate the protective activity of green macro alga, polysaccharides fractions of Ulvafasciata,(U. fasciata)in reno-protection were examined. Cisplatin, (cis-diammine-dichloroplatinum (II), CDDP) is normally used for the treatment of solid tumors that cause acute kidney damage after assemblage in the renal tubules. Biomarkers, anti-inflammatory and antioxidant activity were investigated for the assessment of nephrotoxicity. Furthermore, Gas chromatography–mass spectrometry (GC-MS) technique also performed for phytochemical constituents from green macro alga which revealed the presence of compounds. The
current results showed that polysaccharides fractions of U. fasciatatreatment restored the elevated levels of biomarkers, antioxidant parameters and also showed protection against lipid peroxidation (MDA) induced by cisplatin treatment. n-hexane extract of U. fasciata was subjected to GC-MS analysis which revealed the presence of compounds like; Pentadecanoic acid, Hexadecanoic acid methyl ester, Heptadecane and have been reported to showed antimicrobial, anticancer,antiinflammatory and antioxidant activities. Our findings evidence the pharmacological potential of the U. fasciata has the potential to be used as a therapeutic agent and also as an additional ingredient in
the development of anti-cancer drugs.
Page(s):
190-190
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
GCMS
,
Nephrotoxicity
,
Cisplatin
,
Polysaccharides
,
Ufasciata