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The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice.
Author(s):
1. Chuan Zhou: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
2. Jinlian Li: Department of biological science and technology, Taishan University Tai`an, China
3. Wen Zhang: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
4. Youfei Shi: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
5. Changqi Fu: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
6. Yanmin Wang: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
7. Yan Liu: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
8. Jianzhu Liu: College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, Shandong Agricultural University, Tai`an, China
Abstract:
The present study prepared the pulmonary fibrosis model in mice by using Bleomycin and carry out the investigations on the effects of taurochenodeoxycholic acid (TCDCA) in preventing pulmonary fibrosis in mice. Expression profiles of the bile acid receptors in the lung of mice FXRα and TGR5 were examined, and pulmonary coefficient, pathohistology as well as expression of TNF-α, MMP-2, MMP-9 and TIMP-2 in pulmonary fibrosis mice. The results showed that FXRα and TGR5 simultaneously expressed in the lung of the mice; TCDCA in dosages of 0.05 and 0.1g/kg can extremely significantly decrease the pulmonary coefficient in the model mice (P
Page(s): 761-765
DOI: DOI not available
Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 26, Issue: 4, Year: 2013
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