Synthesis, X-Ray Crystallography and Anti-Inflammatory Evaluation of a Novel Thiosemicarbazide | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Leena Anjum: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan; Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

2. Asia Naz: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,PakistanResearch Institute of Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan

3. Hina Shamshad: Research Institute of Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan

Abstract:

An innovative thiosemicarbazide compound Methyl trimethoxy phenyl hexene thiosemicarbazide (MTHT) was produced by a single pot condensation reaction. Different techniques were used for structure elucidation including chromatography, spectroscopy, and X-ray diffraction. Furthermore, anti-inflammatory response of the synthesized compound was estimated by luminol enhanced chemiluminescence technique through reactive oxygen species. MTHT exhibited more potent antiinflammatory action with IC50 value of 08 ± 0.6 µg/ml in contrast to reference standard ibuprofen. Molecular docking was preferred for determination of possible binding interactions of synthesized compound with Phospholipase A2 protein. Additionally, biological activity was predicted through PASS virtual method

Page(s): 60-60

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

molecular docking , Virtual bioscreening , Thiosemicarbazide , Antiinflammatory agent , XRay Crystallography

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