Acute abdomen: an atypical presentaotin of acquired hemophilia | [Anaesthesia, Pain and Intensive Care • 2024]

Author(s):

1. Muhamad Rafiqi Hehsan: Department of Anesthesiology & Critical Care, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan; Faculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, Bandar Baru Nilai, 71800, Nilai, Negeri Sembilan, Malaysia; Faculty of Medicine, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu Darul Iman, Malaysia

Abstract:

Acquired hemophilia is a rare but potentially life -threatening disorder characterized by the development of acquired hemophilia A, leading to bleeding complications. Spontaneous, mild-to-life-threatening bleeding in typically elderly individuals without a personal or family history of bleeding is the hallmark of acquired hemophilia A (AHA), a rare autoimmune bleeding illness caused by the formation of au to-antibodies against endogenous factor VIII (FVIII). This hallmark represents our present case, with no obvious history related to the bleeding issue. Prompt detecotin and treatment of bleeding are essential for the best outcomes. We present a case of a 66-year-old male who had acute-onset severe abdominal pain and with constipation for five days, associated with nausea and loss of appetite. On physical examination, the patient appeared pale, and abdominal examination revealed diufse tenderness with guar ding. Iniatil evaluation revealed tachycardia and hypotension. Iniatil abdomen X -rays revealed features suggestive of small bowel obstrucotin. The patient was stabilized with intravenous fluids, referred to a surgical team, and admietd to the acute bed in the general ward for further management.

Page(s): 974-976

DOI: 10.35975/apic.v28i5.2556

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 28, Issue: 5, Year: 2024

Keywords:

Autoantibodies , Factor VIII , Acquired Hemophilia , Intraabdominal Bleeding

References:

[1] Dolan G,Benson G,Bowyer A,Eichler H,Hermans C,JiménezYuste V,Bitting RL,Bent S,Li Y,Kohlwes J. .2021 .The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis.. Eur J Haematol, 106(6) : 762-73.

[2] Coagul Fibrinolysis Blood,Gans SL,Pols MA,Stoker J,Boermeester MA .2015 .Guideline for the diagnostic pathway in patients with acute abdominal pain. Dig Surg, 32(1) : 23-31.

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