The effect of inflammatory cytokines on occurrence of retained placenta in cattle | [Advancements in life sciences • 2024]

Author(s):

1. Nawaf Nooraldeen Dhaher: Department of Medicine Surgery and Obstetrics,Veterinary Medicine, TikritUniversity , Iraq

2. Manar Sabah Eesa: Department of Medicine Surgery and Obstetrics,Veterinary Medicine, TikritUniversity , Iraq

3. Hayder A. H. Al-Mutar: Department of Surgery and Obstetric, College of Veterinary Medicine,University of Baghdad, Baghdad , Iraq

4. Maythem Abdulealah Ismaeel: Department of Medicine, Surgery and Obstetrics,Veterinary Medicine, Tikrit University , Iraq

Abstract:

Background: In simple terms, retained placenta is a common issue after parturition in cattle that can affect their reproductive ability. In pregnancies with fetal growth restriction (FGR), the placenta has low anti-inflammatory cytokines and high pro-inflammatory cytokines. By looking at variations in cytokine levels in the blood, we can diagnose the condition. The focus of a recent study was to examine the role of some interleukins (Interleukins -10, Interleukins -6, Interleukins -1ß), C-reactive protein (CRP) and Tumor Necrosis Factor (TNF)-a, in retained placenta occurrence in cattle. Methods: The study involved 40 cows, aged 3-8 years in the Salah-Din province. Each animal suffered from retained placenta also eleven healthy cows served as the control group in a period of January to August 2022. The blood serum was analyzed using enzyme immunoassay techniques (ELIZA) to measure the levels of IL-10, IL-6, IL-1ß, CRP and TNF-a. Results: Serum levels of IL-10, IL-6, IL-1ß, CRP and TNF-a showed a significant increase in cows experiencing retained fetal membranes compared to healthy cows (2.31±0.11 vs 1.41 ±0.07) (10.48±0.24 vs 5.40±0.19), (13.6±2.1 vs 4±0.9), (0.9±0.02 vs 0.32±0.04) and (60.1 ± 12.79 vs 29.5 ± 16.58) respectively. Conclusion: from the present study we conclude that IL10, IL6, IL1ß and TNFa play an essential component in retained placenta incidence, and the estimation levels of these parameters in serum may be considered good indicator for occurrence in cattle. RT-PCR revealed increased expression of SDHA genes in the maternal compartment of the placenta.

Page(s): 414-418

DOI: DOI not available

Published: Journal: Advancements in life sciences, Volume: 11, Issue: 2, Year: 2024

Keywords:

Creactive protein , Retained placenta Cytokines

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