The efect of dapagliflozin on renal functions in hospitalized patients with acute heart failure | [Pakistan Journal of Medical Sciences • 2023]

Author(s):

1. Syedah Fauzia Fatima Gilani: Pharmacology Department, Army Medical College,Rawalpindi,Pakistan

2. Shabana Ali: Pharmacology Department, Army Medical College,Rawalpindi,Pakistan

3. Muhammad Bilal Siddique: Armed Forces Institute of Cardiology, Rawalpindi, Pakistan.

4. Kulsoom Farhat: Pharmacology Department, Army Medical College,Rawalpindi,Pakistan

5. Mudassar Noor: Pharmacology Department, Army Medical College,Rawalpindi,Pakistan

6. Farzana Waqar: Pharmacology Department, Army Medical College,Rawalpindi,Pakistan

Abstract:

Objective: To evaluate the influence of dapagliflozin on renal functions and diuretics use in patients with acute heart failure (AHF). Methods: This comparative analytical study was conducted at Armed Forces Institute of Cardiology, Rawalpindi from July 2022 to November 2022. Patients were distributed equally in two groups i.e. Dapagliflozin and Conventional Groups, where patients received dapagliflozin added to conventional therapy for AHF and, only conventional therapy for AHF respectively. Estimated glomerular filtration rate (eGFR), serum creatinine were measured and compared on admission, after 48 hours and on discharge. Weight loss during hospitalization, daily dose of furosemide and length of hospital stay was also recorded. Quantitative parameters were analyzed using t-test or Mann Whitney U test accordingly. Results: There were no significant baseline diferences in renal functions. A modest decline in eGFR was observed in both groups after 48 hours. However, the variation in values of eGFR remained similar among both groups after 48 hours (p-value 0.365) and on discharge (p-value 0.768). Whereas, patients subjected to dapagliflozin treatment exhibited a more profound diuretic response expressed as greater weight loss (p-value < 0.001), achieved at comparatively lower doses of loop diuretics. Moreover, they also had a shorter duration of hospital stay (six vs eight days, p-value <0.001). Conclusion: Institution of dapagliflozin did not cause any significant deterioration of renal functions, whereas; it was associated with improved diuretic response as depicted by more pronounced weight loss at comparatively lower doses of loop diuretics.

Page(s): 1695-1700

DOI: 10.12669/pjms.39.6.7525

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 39, Issue: 6, Year: 2023

Keywords:

Serum creatinine , eGFR , Acute heart failure , Dapagliflozin

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